Expression of Mutant RPA in Human Cancer Cells Causes Telomere Shortening

Yuka KOBAYASHI; Koichiro SATO; Tatsuya KIBE; Hiroyuki SEIMIYA; Asako NAKAMURA; Masashi YUKAWA; Eiko TSUCHIYA; Masaru UENO

doi:10.1271/bbb.90496

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Expression of Mutant RPA in Human Cancer Cells Causes Telomere Shortening

Yuka KOBAYASHI, Koichiro SATO, Tatsuya KIBE, Hiroyuki SEIMIYA, Asako NAKAMURA, Masashi YUKAWA, Eiko TSUCHIYA, Masaru UENO

著者情報

キーワード: replication protein A, telomere, human cancer cells

ジャーナルフリー早期公開

論文ID: 90496

DOI https://doi.org/10.1271/bbb.90496

この記事には本公開記事があります。

The final version of this article is now available: Vol. 74 (2010) , No. 2 p.382

詳細

抄録

Replication protein A (RPA) binds to single-stranded DNA generated during DNA replication and other processes. The roles of RPA in telomere maintenance have been demonstrated in yeasts, but not in telomerase-positive human cells. In this study, we found that expression of mutant RPA70 in human cells caused telomere shortening, suggesting that RPA is required for telomere-length regulation in human cancer cells.

責任著者(Corresponding author)

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