Precursor-Directed Biosynthesis of Curcumin Analogs in Escherichia coli

Yohei KATSUYAMA; Yutaka HIROSE; Nobutaka FUNA; Yasuo OHNISHI; Sueharu HORINOUCHI

doi:10.1271/bbb.90866

Microbiology & Fermentation Technology Regular Papers

Precursor-Directed Biosynthesis of Curcumin Analogs in Escherichia coli

Yohei KATSUYAMA, Yutaka HIROSE, Nobutaka FUNA, Yasuo OHNISHI, Sueharu HORINOUCHI

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Keywords: curcuminoid, curcumin, polyketide synthase, precursor-directed biosynthesis, microbial production

JOURNAL FREE ACCESS

2010 Volume 74 Issue 3 Pages 641-645

DOI https://doi.org/10.1271/bbb.90866

View "Advance Publication" version (March 7, 2010).

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Abstract

Curcuminoids, natural products in the rhizome of turmeric, show various biological activities, including antioxidant and antitumor activities. For this reason, curcuminoids have been focused on as potential pharmaceuticals. Exogenous supplementation with various carboxylate precursors in genetically engineered Escherichia coli cells carrying an artificially assembled pathway for curcuminoid biosynthesis led to the production of 17 unnatural curcuminoids.

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