Precursor-Directed Biosynthesis of Curcumin Analogs in Escherichia coli

Yohei KATSUYAMA; Yutaka HIROSE; Nobutaka FUNA; Yasuo OHNISHI; Sueharu HORINOUCHI

doi:10.1271/bbb.90866

This article has now been updated. Please use the final version.

Precursor-Directed Biosynthesis of Curcumin Analogs in Escherichia coli

Yohei KATSUYAMA, Yutaka HIROSE, Nobutaka FUNA, Yasuo OHNISHI, Sueharu HORINOUCHI

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Keywords: curcuminoid, curcumin, polyketide synthase, precursor-directed biosynthesis, microbial production

JOURNAL FREE ACCESS Advance online publication

Article ID: 90866

DOI https://doi.org/10.1271/bbb.90866

The final version of this article is now available: Vol. 74 (2010) , No. 3 p.641

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Abstract

Curcuminoids, natural products in the rhizome of turmeric, show various biological activities, including antioxidant and antitumor activities. For this reason, curcuminoids have been focused on as potential pharmaceuticals. Exogenous supplementation with various carboxylate precursors in genetically engineered Escherichia coli cells carrying an artificially assembled pathway for curcuminoid biosynthesis led to the production of 17 unnatural curcuminoids.

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