Soybean Lipoxygenase Inhibitory and DPPH Radical-Scavenging Activities of Aspernolide A and Butyrolactones I and II

Yasumasa SUGIYAMA; Kayo YOSHIDA; Naoki ABE; Akira HIROTA

doi:10.1271/bbb.90918

Organic Chemistry Notes

Soybean Lipoxygenase Inhibitory and DPPH Radical-Scavenging Activities of Aspernolide A and Butyrolactones I and II

Yasumasa SUGIYAMA, Kayo YOSHIDA, Naoki ABE, Akira HIROTA

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Keywords: soybean lipoxygenase inhibitor, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenger, aspernolide A, butyrolactones I and II, quinone methide

JOURNAL FREE ACCESS

2010 Volume 74 Issue 4 Pages 881-883

DOI https://doi.org/10.1271/bbb.90918

View "Advance Publication" version (April 7, 2010).

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Abstract

Aspernolide A and butyrolactones I and II showed inhibitory activities against soybean lipoxygenase. All of them also had DPPH (2,2-diphenyl-1-picrylhydrazyl) radical-scavenging activity. An analysis of the mechanism for radical scavenging allowed us to deduce that aspernolide A was converted to a quinone methide by a reaction with two molecules of the DPPH radical.

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