Inhibition by Genistein of the Lipopolysaccharide-Induced Down-Regulation of Programmed Cell Death 4 in RAW 264.7 Mouse Macrophages

Abstract

Programmed cell death 4 (Pdcd4), a novel tumor suppressor, has recently emerged as an anti-inflammatory protein. We assessed in the present study the effects of 18 different food factors with anti-inflammatory activity on the lipopolysaccharide-induced down-regulation of pdcd4 mRNA expression in mouse RAW 264.7 macrophages. Genistein, a soy isoflavone, significantly inhibited pdcd4 down-regulation.