Effect of Neuroprotective Flavonoids of Agrimonia eupatoria on Glutamate-Induced Oxidative Injury to HT22 Hippocampal Cells

Ki Yong LEE; Lim HWANG; Eun Ju JEONG; Seung Hyun KIM; Young Choong KIM; Sang Hyun SUNG

doi:10.1271/bbb.100200

Organic Chemistry Note

Effect of Neuroprotective Flavonoids of Agrimonia eupatoria on Glutamate-Induced Oxidative Injury to HT22 Hippocampal Cells

Ki Yong LEE, Lim HWANG, Eun Ju JEONG, Seung Hyun KIM, Young Choong KIM, Sang Hyun SUNG

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Keywords: Agrimonia eupatoria, Lauraceae, HT22 hippocampal cell, neuroprotective, flavonoid

JOURNAL FREE ACCESS

2010 Volume 74 Issue 8 Pages 1704-1706

DOI https://doi.org/10.1271/bbb.100200

View "Advance Publication" version (August 7, 2010).

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Abstract

A methanolic extract of Agrimonia eupatoria (Rosaceae) significantly attenuated glutamate-induced oxidative stress in HT22 hippocampal cells. A new flavonoid, characterized as kaempferol 3-O-β-D-(2″-O-acetyl-6″-(E)-p-coumaroyl)-glucopyranoside (2″-acetyl-tiliroside (1), was isolated from the methanolic extract of A. eupatoria stems together with nine known flavonoids. Compounds 4, 7, 8 and 9 all showed a neuroprotective effect on glutamate-induced toxicity in HT22 cells.

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