Effective Cytochrome P450 (CYP) Inhibitor Isolated from Thyme (Thymus saturoides) Purchased from a Japanese Market

Zeineb BRAHMI; Hitomi NIWA; Mio YAMASATO; Sakurako SHIGETO; Yuna KUSAKARI; Kouichi SUGAYA; Jun-ichi ONOSE; Naoki ABE

doi:10.1271/bbb.110328

Organic Chemistry Notes

Effective Cytochrome P450 (CYP) Inhibitor Isolated from Thyme (Thymus saturoides) Purchased from a Japanese Market

Zeineb BRAHMI, Hitomi NIWA, Mio YAMASATO, Sakurako SHIGETO, Yuna KUSAKARI, Kouichi SUGAYA, Jun-ichi ONOSE, Naoki ABE

著者情報

キーワード: 8-methoxycirsilineol, cytochrome P450 (CYP) inhibitor, Thymus saturoides, polymethoxyflavone

ジャーナルフリー

2011 年 75 巻 11 号 p. 2237-2239

DOI https://doi.org/10.1271/bbb.110328

View "Advance Publication" version (November 7, 2011).

詳細

抄録

A highly polymethylated flavone that effectively inhibited cytochrome P450s (CYPs) 1A2 and 3A4 (IC₅₀=2.41 and 1.71 μM) in vitro was isolated from thyme leaves (Thymus saturoides) purchased from a Japanese market. Its structure was spectroscopically identified as 4′,5-dihydroxy-3′,6,7,8-tetramethoxy flavone (8-methoxycirsilineol, 1). This is the first report describing a strong inhibitor of CYP1A2 and 3A4 isolated from Thymus saturoides.

責任著者(Corresponding author)

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