Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Organic Chemistry Notes
Ganodermasides C and D, Two New Anti-Aging Ergosterols from Spores of the Medicinal Mushroom Ganoderma lucidum
Yufang WENGJun LULan XIANGAkira MATSUURAYang ZHANGQianming HUANGJianhua QI
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2011 Volume 75 Issue 4 Pages 800-803

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Abstract

Two new anti-aging compounds, ganodermasides C and D, were isolated and their structures elucidated. They are novel ergosterols possessing a 4,6,8(14),22-tetraene-3-one unit with unique hydroxylation at C-9. Both of them significantly extended the replicative lifespan of the K6001 yeast strain. Ganodermasides C and D regulated the expression of the gene for UTH1 to prolong the replicative lifespan of yeast.

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© 2011 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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