Ganodermasides C and D, Two New Anti-Aging Ergosterols from Spores of the Medicinal Mushroom Ganoderma lucidum

Yufang WENG; Jun LU; Lan XIANG; Akira MATSUURA; Yang ZHANG; Qianming HUANG; Jianhua QI

doi:10.1271/bbb.100918

Organic Chemistry Notes

Ganodermasides C and D, Two New Anti-Aging Ergosterols from Spores of the Medicinal Mushroom Ganoderma lucidum

Yufang WENG, Jun LU, Lan XIANG, Akira MATSUURA, Yang ZHANG, Qianming HUANG, Jianhua QI

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Keywords: spores of Ganoderma lucidum, ganodermaside, anti-aging, K6001 yeast strain, UTH1 gene

JOURNAL FREE ACCESS

2011 Volume 75 Issue 4 Pages 800-803

DOI https://doi.org/10.1271/bbb.100918

View "Advance Publication" version (April 22, 2011).

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Abstract

Two new anti-aging compounds, ganodermasides C and D, were isolated and their structures elucidated. They are novel ergosterols possessing a 4,6,8(14),22-tetraene-3-one unit with unique hydroxylation at C-9. Both of them significantly extended the replicative lifespan of the K6001 yeast strain. Ganodermasides C and D regulated the expression of the gene for UTH1 to prolong the replicative lifespan of yeast.

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