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Bioscience, Biotechnology, and Biochemistry
Vol. 75 (2011) No. 4 P 800-803

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http://doi.org/10.1271/bbb.100918

Organic Chemistry Notes

Two new anti-aging compounds, ganodermasides C and D, were isolated and their structures elucidated. They are novel ergosterols possessing a 4,6,8(14),22-tetraene-3-one unit with unique hydroxylation at C-9. Both of them significantly extended the replicative lifespan of the K6001 yeast strain. Ganodermasides C and D regulated the expression of the gene for UTH1 to prolong the replicative lifespan of yeast.

Copyright © 2011 by Japan Society for Bioscience, Biotechnology, and Agrochemistry

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