The Mucin Box and Signal/Anchor Sequence of Rat Neutral Ceramidase Recruit Bacterial Sphingomyelinase to the Plasma Membrane

Tetsuto NAKAGAWA; Motohiro TANI; Noriyuki SUEYOSHI; Makoto ITO

doi:10.1271/bbb.100767

Biochemistry & Molecular Biology Notes

The Mucin Box and Signal/Anchor Sequence of Rat Neutral Ceramidase Recruit Bacterial Sphingomyelinase to the Plasma Membrane

Tetsuto NAKAGAWA, Motohiro TANI, Noriyuki SUEYOSHI, Makoto ITO

著者情報

キーワード: cell-surface expression, mucin box, neutral ceramidase, Pseudomonas sphingomyelinase, sphingomyelin

ジャーナルフリー

2011 年 75 巻 5 号 p. 987-990

DOI https://doi.org/10.1271/bbb.100767

View "Advance Publication" version (May 20, 2011).

詳細

抄録

Sphingolipid metabolites act as lipid mediators in various cellular events. We found that the mucin box and signal/anchor sequence of a rat neutral ceramidase recruit bacterial sphingomyelinase to the plasma membranes of mammalian cells. The mucin box-fused sphingomyelinase hydrolyzed cellular sphingomyelin efficiently to generate ceramide.

責任著者(Corresponding author)

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