Fish Oil Feeding Up-Regulates the Expression of 5-Aminolevulinate Synthase 2 mRNA in Rat Brain

Tomoaki HARAGUCHI; Noriyuki YANAKA; Yuko EGUCHI; Takahiro KUDO; Atsuko HIRATA; Norihisa KATO

doi:10.1271/bbb.110121

Biochemistry & Molecular Biology Notes

Fish Oil Feeding Up-Regulates the Expression of 5-Aminolevulinate Synthase 2 mRNA in Rat Brain

Tomoaki HARAGUCHI, Noriyuki YANAKA, Yuko EGUCHI, Takahiro KUDO, Atsuko HIRATA, Norihisa KATO

著者情報

キーワード: 5-aminolevulinate synthase, fish oil, docosahexaenoic acid

ジャーナルフリー

2011 年 75 巻 7 号 p. 1383-1385

DOI https://doi.org/10.1271/bbb.110121

View "Advance Publication" version (July 7, 2011).

詳細

抄録

In this study, we investigated the effect of fish oil on gene expression in the cerebral cortex, and found that 5-aminolevulinate synthase 2 (ALAS2) mRNA expression was up-regulated by fish oil feeding. ALAS2 promoter activity was found to be regulated by retinoic acid. Our results suggest that fish oil modulates neuronal functions via heme synthesis.

責任著者(Corresponding author)

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