Neuroprotective Kaurane Diterpenes from Fritillaria ebeiensis

Jing XU; Ping GUO; Cuizhou LIU; Zhanping SUN; Liping GUI; Yuanqiang GUO; Tohru YAMAKUNI; Yasushi OHIZUMI

doi:10.1271/bbb.110146

Organic Chemistry Notes

Neuroprotective Kaurane Diterpenes from Fritillaria ebeiensis

Jing XU, Ping GUO, Cuizhou LIU, Zhanping SUN, Liping GUI, Yuanqiang GUO, Tohru YAMAKUNI, Yasushi OHIZUMI

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Keywords: Fritillaria ebeiensis, dietrpenoids, kaurane, neuroprotective effect

JOURNAL FREE ACCESS

2011 Volume 75 Issue 7 Pages 1386-1388

DOI https://doi.org/10.1271/bbb.110146

View "Advance Publication" version (July 7, 2011).

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Abstract

The new kaurane diterpene, ent-3β-butanoyloxykaur-15-en-17-ol, and four known kaurane diterpenes were isolated from the bulbs of Fritillaria ebeiensis. Their structures were elucidated on the basis of extensive spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, 1-D and 2-D NMR). All the isolates showed neuroprotective effects against MPP⁺-induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells.

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