Neuroprotective Kaurane Diterpenes from Fritillaria ebeiensis

Jing XU; Ping GUO; Cuizhou LIU; Zhanping SUN; Liping GUI; Yuanqiang GUO; Tohru YAMAKUNI; Yasushi OHIZUMI

doi:10.1271/bbb.110146

This article has now been updated. Please use the final version.

Neuroprotective Kaurane Diterpenes from Fritillaria ebeiensis

Jing XU, Ping GUO, Cuizhou LIU, Zhanping SUN, Liping GUI, Yuanqiang GUO, Tohru YAMAKUNI, Yasushi OHIZUMI

Author information

Keywords: Fritillaria ebeiensis, dietrpenoids, kaurane, neuroprotective effect

JOURNAL FREE ACCESS Advance online publication

Article ID: 110146

DOI https://doi.org/10.1271/bbb.110146

The final version of this article is now available: Vol. 75 (2011) , No. 7 p.1386

Details

Abstract

The new kaurane diterpene, ent-3β-butanoyloxykaur-15-en-17-ol, and four known kaurane diterpenes were isolated from the bulbs of Fritillaria ebeiensis. Their structures were elucidated on the basis of extensive spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, 1-D and 2-D NMR). All the isolates showed neuroprotective effects against MPP⁺-induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells.

Corresponding author

Register with J-STAGE for free!