A Novel Compound, L34, Induced Apoptosis in Human Gastric Cancer Cells

Yuchen LIN; Yangling LI; Guiyuan LU; Jing CHEN

doi:10.1271/bbb.110200

Biochemistry & Molecular Biology Notes

A Novel Compound, L34, Induced Apoptosis in Human Gastric Cancer Cells

Yuchen LIN, Yangling LI, Guiyuan LU, Jing CHEN

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Keywords: anticancer compound, L34, apoptosis, gastric cancer

JOURNAL FREE ACCESS

2011 Volume 75 Issue 9 Pages 1826-1828

DOI https://doi.org/10.1271/bbb.110200

View "Advance Publication" version (September 7, 2011).

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Abstract

Selectively apoptosis-targeting compounds in gastrointestinal cancers attract broad interest. Here, we investigated a synthetic sulfonamide, 4-bromo-N-(5-ethyl-5H-pyrido[4,3-b]indol-8-yl)benzenesulfonamide (L34). It showed high activity against gastric cancer cells SGC-7901, causing apoptosis, which was associated with downregulation of caspase-3 and XIAP, upegulation of cleaved caspase-3, and cleavage of PARP. Hence, L34 might be a potent chemotherapeutic agent against human gastric cancer.

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