Actin Stress Fiber Retraction and Aggresome Formation Is a Common Cellular Response to Actin Toxins

Sayaka KAZAMI; Takeo USUI; Hiroyuki OSADA

doi:10.1271/bbb.110334

Biochemistry & Molecular Biology Notes

Actin Stress Fiber Retraction and Aggresome Formation Is a Common Cellular Response to Actin Toxins

Sayaka KAZAMI, Takeo USUI, Hiroyuki OSADA

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Keywords: actin, actin toxin, aggresome, latrunculin A

JOURNAL FREE ACCESS

2011 Volume 75 Issue 9 Pages 1853-1855

DOI https://doi.org/10.1271/bbb.110334

View "Advance Publication" version (September 7, 2011).

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Abstract

F-actin-stabilizing drugs induce actin aggresome formation. In this study, we found that an actin-depolymerizing drug, latrunculin A (LatA), induced actin aggresomes. Actin stress fibers were retracted and disappeared in minutes, but a large aggresome formed in consequence of LatA treatment. Because cytochalasin D and mycalolide also induced aggresome formation, these results suggest that actin aggresome formation is a common cellular response to actin toxins.

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