Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Food & Nutrition Science Regular Papers
Inhibitory Effects of Water-Soluble Low-Molecular-Weight β-(1,3-1,6) D-Glucan Isolated from Aureobasidium pullulans 1A1 Strain Black Yeast on Mast Cell Degranulation and Passive Cutaneous Anaphylaxis
Harumi SATOYuko KOBAYASHIAtsushi HATTORIToshio SUZUKIMunekazu SHIGEKAWATomoko JIPPO
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2012 Volume 76 Issue 1 Pages 84-88

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Abstract

We investigated the effects of water-soluble low-molecular-weight β-(1,3-1,6) D-glucan isolated from Aureobasidium pullulans 1A1 strain black yeast (LMW-β-glucan) on mast cell-mediated anaphylactic reactions. Although it is known that LMW-β-glucan has anti-tumor, anti-metastatic and anti-stress effects, the roles of LMW-β-glucan in immediate-type allergic reactions have not been fully investigated. We examined whether LMW-β-glucan could inhibit mast cell degranulation and passive cutaneous anaphylaxis (PCA). LMW-β-glucan dose-dependently inhibited the degranulation of both rat basophilic leukemia (RBL-2H3) and cultured mast cells (CMCs) activated by calcium ionophore A23187 or IgE. However, LMW-β-glucan had no cytotoxicity towards RBL-2H3 cells and CMCs. Furthermore, orally administered LMW-β-glucan inhibited the IgE-induced PCA reaction in mice. These results show LMW-β-glucan to be a possible compound for the effective therapeutic treatment of allergic diseases.

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© 2012 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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