Daintain/AIF-1 Reinforces the Resistance of Breast Cancer Cells to Cisplatin

Shaohui JIA; Moctar Ali CHAIBOU; Zhengwang CHEN

doi:10.1271/bbb.120577

Biochemistry & Molecular Biology Notes

Daintain/AIF-1 Reinforces the Resistance of Breast Cancer Cells to Cisplatin

Shaohui JIA, Moctar Ali CHAIBOU, Zhengwang CHEN

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Keywords: daintain/AIF-1, cisplatin, breast cancer cells, apoptosis, efflux

JOURNAL FREE ACCESS

2012 Volume 76 Issue 12 Pages 2338-2341

DOI https://doi.org/10.1271/bbb.120577

View "Advance Publication" version (December 7, 2012).

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Abstract

Our previous studies revealed that daintain/AIF-1 promoted the proliferation and migration of breast cancer cells. In the present study, we investigated the effect of daintain/AIF-1 on the cisplatin resistance of breast cancer cells. The results indicated that daintain/AIF-1 reinforced the resistance of breast cancer cells to cisplatin by inhibition of cell apoptosis and reduction of intracellular cisplatin accumulation.

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