Cytotoxic Steroids from the Trunk of Berberis koreana

Ki Hyun KIM; Sang Un CHOI; Chung Sub KIM; Kang Ro LEE

doi:10.1271/bbb.110751

Organic Chemistry Notes

Cytotoxic Steroids from the Trunk of Berberis koreana

Ki Hyun KIM, Sang Un CHOI, Chung Sub KIM, Kang Ro LEE

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Keywords: Berberis koreana, Berberidaceae, steroid, itesmol 3-O-palmitate, cytotoxicity

JOURNAL FREE ACCESS

2012 Volume 76 Issue 4 Pages 825-827

DOI https://doi.org/10.1271/bbb.110751

View "Advance Publication" version (April 7, 2012).

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Abstract

A new steroid, itesmol 3-O-palmitate (1), along with two known steroids were isolated from the trunk of Berberis koreana. The structure of 1 was determined on the basis of spectroscopic analyses involving 2D NMR and chemical reactions. Compound 1 exhibited potential antiproliferative activity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines (respective IC₅₀ values of 7.41, 9.20, 4.53, and 12.91 μM).

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