Screening and Identification of Disaccharides with Insulin Mimetic Activity against L6 Cells

Kazuaki YAMASAKI; Ryogo HISHIKI; Eisuke KATO; Jun KAWABATA

doi:10.1271/bbb.110884

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Organic Chemistry Notes

Screening and Identification of Disaccharides with Insulin Mimetic Activity against L6 Cells

Kazuaki YAMASAKI, Ryogo HISHIKI, Eisuke KATO, Jun KAWABATA

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Keywords: insulin mimetic, disaccharide, diabetes mellitus, glucose uptake, L6 cell

JOURNAL FREE ACCESS

2012 Volume 76 Issue 4 Pages 841-842

DOI https://doi.org/10.1271/bbb.110884

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Abstract

Insulin mimetics are considered as prospective anti-diabetic agents, and the disaccharide, neohesperidose, has been found to show insulin mimetic activity against L6 cells. We screened several other disaccharides for their insulin mimetic activity and identified three new insulin mimetic disaccharides.

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