Comparison of the Efficacy of Alpha-Lactalbumin from Equine, Bovine, and Human Milk in the Growth of Intestinal IEC-6 Cells

XIJIER; Yuki MORI; Mayuko FUKUOKA; CAIRANGZHUOMA; Mizuho INAGAKI; Satoshi IWAMOTO; Tomio YABE; Yoshihiro KANAMARU

doi:10.1271/bbb.110896

Food & Nutrition Science Notes

Comparison of the Efficacy of Alpha-Lactalbumin from Equine, Bovine, and Human Milk in the Growth of Intestinal IEC-6 Cells

XIJIER, Yuki MORI, Mayuko FUKUOKA, CAIRANGZHUOMA, Mizuho INAGAKI, Satoshi IWAMOTO, Tomio YABE, Yoshihiro KANAMARU

Author information

XIJIER
United Graduate School of Agricultural Science, Gifu University
Yuki MORI
Department of Applied Life Science, Gifu University
Mayuko FUKUOKA
Department of Applied Life Science, Gifu University
CAIRANGZHUOMA
United Graduate School of Agricultural Science, Gifu University
Mizuho INAGAKI
Department of Applied Life Science, Gifu University
Satoshi IWAMOTO
United Graduate School of Agricultural Science, Gifu University
Department of Applied Life Science, Gifu University
Tomio YABE
United Graduate School of Agricultural Science, Gifu University
Department of Applied Life Science, Gifu University
Yoshihiro KANAMARU
United Graduate School of Agricultural Science, Gifu University
Department of Applied Life Science, Gifu University

Keywords: α-lactalbumin, 2,2,2-trifluoroethanol, IEC-6 cells, cell death

JOURNAL FREE ACCESS

2012 Volume 76 Issue 4 Pages 843-846

DOI https://doi.org/10.1271/bbb.110896

View "Advance Publication" version (April 7, 2012).

Details

Abstract

Native alpha-lactalbumins (α-LA) from equine, bovine, and human milk were not cytotoxic. However, after treatment with trifluoroethanol (TFE), all three α-LAs exhibited cytotoxicity. Toxic potencies were distinctly different among them. Equine α-LA was the most robust, bovine α-LA was moderate, and human α-LA was weak. There were no significant structural changes as between the native and the TFE-treated α-LAs.

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