Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Organic Chemistry Notes
Identification and Biological Activities of Bryostatins from Japanese Bryozoan
Sayo UENORyo C. YANAGITAKazuma MURAKAMIAkira MURAKAMIHarukuni TOKUDANobutaka SUZUKITakeshi FUJIWARAKazuhiro IRIE
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2012 Volume 76 Issue 5 Pages 1041-1043

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Abstract

Six bryostatins were isolated from Japanese bryozoan by evaluating their binding to the C1B domain of protein kinase Cδ (PKCδ). Structure-activity studies of bryostatins 4, 10, and 14 suggested that the ester group at C20 was not necessary for binding to and activating PKCδ. These bryostatins showed significant anti-tumor-promoting activity in induction tests with the Epstein-Barr virus early antigen.

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© 2012 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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