Identification and Biological Activities of Bryostatins from Japanese Bryozoan

Sayo UENO; Ryo C. YANAGITA; Kazuma MURAKAMI; Akira MURAKAMI; Harukuni TOKUDA; Nobutaka SUZUKI; Takeshi FUJIWARA; Kazuhiro IRIE

doi:10.1271/bbb.120026

Organic Chemistry Notes

Identification and Biological Activities of Bryostatins from Japanese Bryozoan

Sayo UENO, Ryo C. YANAGITA, Kazuma MURAKAMI, Akira MURAKAMI, Harukuni TOKUDA, Nobutaka SUZUKI, Takeshi FUJIWARA, Kazuhiro IRIE

Author information

Sayo UENO
Department of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
Ryo C. YANAGITA
Department of Applied Biological Science, Faculty of Agriculture, Kagawa University
Kazuma MURAKAMI
Department of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
Akira MURAKAMI
Department of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
Harukuni TOKUDA
Department of Complementary and Alternative Medicine Clinical R&D, Graduate School of Medical Science, Kanazawa University
Nobutaka SUZUKI
Department of Complementary and Alternative Medicine Clinical R&D, Graduate School of Medical Science, Kanazawa University
Takeshi FUJIWARA
OP-BIO Factory Co., Ltd.
Kazuhiro IRIE
Department of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

Keywords: protein kinase C, bryostatin, Bugula neritina, tumor promotion, Epstein-Barr virus

JOURNAL FREE ACCESS

2012 Volume 76 Issue 5 Pages 1041-1043

DOI https://doi.org/10.1271/bbb.120026

View "Advance Publication" version (May 7, 2012).

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Abstract

Six bryostatins were isolated from Japanese bryozoan by evaluating their binding to the C1B domain of protein kinase Cδ (PKCδ). Structure-activity studies of bryostatins 4, 10, and 14 suggested that the ester group at C20 was not necessary for binding to and activating PKCδ. These bryostatins showed significant anti-tumor-promoting activity in induction tests with the Epstein-Barr virus early antigen.

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