Cytotoxic Prodigiosin Family Pigments from Pseudoalteromonas sp. 1020R Isolated from the Pacific Coast of Japan

Yi WANG; Aya NAKAJIMA; Kakushi HOSOKAWA; Azamjon B. SOLIEV; Issey OSAKA; Ryuichi ARAKAWA; Keiichi ENOMOTO

doi:10.1271/bbb.110984

Biochemistry & Molecular Biology Notes

Cytotoxic Prodigiosin Family Pigments from Pseudoalteromonas sp. 1020R Isolated from the Pacific Coast of Japan

Yi WANG, Aya NAKAJIMA, Kakushi HOSOKAWA, Azamjon B. SOLIEV, Issey OSAKA, Ryuichi ARAKAWA, Keiichi ENOMOTO

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Keywords: Pseudoalteromonas, prodigiosin, cytotoxicity, apoptosis

JOURNAL FREE ACCESS

2012 Volume 76 Issue 6 Pages 1229-1232

DOI https://doi.org/10.1271/bbb.110984

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Abstract

Pseudoalteromonas sp. 1020R, isolated from the Pacific coast of Japan, produces prodigiosin family pigments. Structural analysis indicated that these are prodigiosin (2-methyl-3-pentyl-prodiginine) and three other prodigiosin congeners which differ only in the lengths of the alkyl side chains. These compounds exhibited different extents of cytotoxicity against U937 leukemia cells, and cell death was accompanied by typical features of apoptosis.

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