Cytotoxic Prodigiosin Family Pigments from Pseudoalteromonas sp. 1020R Isolated from the Pacific Coast of Japan

Yi WANG; Aya NAKAJIMA; Kakushi HOSOKAWA; Azamjon B. SOLIEV; Issey OSAKA; Ryuichi ARAKAWA; Keiichi ENOMOTO

doi:10.1271/bbb.110984

Biochemistry & Molecular Biology Notes

Cytotoxic Prodigiosin Family Pigments from Pseudoalteromonas sp. 1020R Isolated from the Pacific Coast of Japan

Yi WANG, Aya NAKAJIMA, Kakushi HOSOKAWA, Azamjon B. SOLIEV, Issey OSAKA, Ryuichi ARAKAWA, Keiichi ENOMOTO

著者情報

キーワード: Pseudoalteromonas, prodigiosin, cytotoxicity, apoptosis

ジャーナルフリー

2012 年 76 巻 6 号 p. 1229-1232

DOI https://doi.org/10.1271/bbb.110984

View "Advance Publication" version (June 7, 2012).

詳細

抄録

Pseudoalteromonas sp. 1020R, isolated from the Pacific coast of Japan, produces prodigiosin family pigments. Structural analysis indicated that these are prodigiosin (2-methyl-3-pentyl-prodiginine) and three other prodigiosin congeners which differ only in the lengths of the alkyl side chains. These compounds exhibited different extents of cytotoxicity against U937 leukemia cells, and cell death was accompanied by typical features of apoptosis.

責任著者(Corresponding author)

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