Cytotoxic Prodigiosin Family Pigments from Pseudoalteromonas sp. 1020R Isolated from the Pacific Coast of Japan

Yi WANG; Aya NAKAJIMA; Kakushi HOSOKAWA; Azamjon B. SOLIEV; Issey OSAKA; Ryuichi ARAKAWA; Keiichi ENOMOTO

doi:10.1271/bbb.110984

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Cytotoxic Prodigiosin Family Pigments from Pseudoalteromonas sp. 1020R Isolated from the Pacific Coast of Japan

Yi WANG, Aya NAKAJIMA, Kakushi HOSOKAWA, Azamjon B. SOLIEV, Issey OSAKA, Ryuichi ARAKAWA, Keiichi ENOMOTO

著者情報

キーワード: Pseudoalteromonas, prodigiosin, cytotoxicity, apoptosis

ジャーナルフリー早期公開

論文ID: 110984

DOI https://doi.org/10.1271/bbb.110984

この記事には本公開記事があります。

The final version of this article is now available: Vol. 76 (2012) , No. 6 p.1229

詳細

抄録

Pseudoalteromonas sp. 1020R, isolated from the Pacific coast of Japan, produces prodigiosin family pigments. Structural analysis indicated that these are prodigiosin (2-methyl-3-pentyl-prodiginine) and three other prodigiosin congeners which differ only in the lengths of the alkyl side chains. These compounds exhibited different extents of cytotoxicity against U937 leukemia cells, and cell death was accompanied by typical features of apoptosis.

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