Synthesis of Sphingolipids with an ω-Esterified Long Acyl Chain, Ceramide Components of the Human Epidermis

Takuya TASHIRO; Kenji MORI

doi:10.1271/bbb.120333

Organic Chemistry Regular Papers

Synthesis of Sphingolipids with an ω-Esterified Long Acyl Chain, Ceramide Components of the Human Epidermis

Takuya TASHIRO, Kenji MORI

著者情報

キーワード: ceramide, olefin cross metathesis, epidermis, sphingolipid, stratum corneum

ジャーナルフリー

2012 年 76 巻 9 号 p. 1715-1720

DOI https://doi.org/10.1271/bbb.120333

View "Advance Publication" version (September 7, 2012).

詳細

抄録

Esterified ceramides, (2S,3R,4E)-2-[(30'-stearoyloxy)triacontanamido]octadec-4-ene-1,3-diol (2) and (2S,3R,4E,6R)-2-[(30'-stearoyloxy)triacontanamido]octadec-4-ene-1,3,6-triol (4), are minor components of the human stratum corneum. We synthesized these ceramides by employing olefin cross metathesis as the key reaction for constructing their ω-hydroxytriacontanoyl part (13).

責任著者(Corresponding author)

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