Lignan Glucosides from Sinomenium acutum Rhizomes

Ki Hyun KIM; Sae Rom MOON; Chung Sub KIM; Kyeong Wan WOO; Sang Un CHOI; Kang Ro LEE

doi:10.1271/bbb.130445

Analytical Chemistry Note

Lignan Glucosides from Sinomenium acutum Rhizomes

Ki Hyun KIM, Sae Rom MOON, Chung Sub KIM, Kyeong Wan WOO, Sang Un CHOI, Kang Ro LEE

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Keywords: Sinomenium acutum, Menispermaceae, lignan, acutumoside, cytotoxicity

JOURNAL FREE ACCESS

2013 Volume 77 Issue 10 Pages 2144-2147

DOI https://doi.org/10.1271/bbb.130445

View "Advance Publication" version (October 7, 2013).

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Abstract

The new lignan glucoside, acutumoside (1), was isolated from Sinomenium acutum rhizomes together with nine known compounds (2–10). The structure of 1 was elucidated on the basis of extensive spectroscopic analyses, including two-dimensional nuclear magnetic resonance and chemical reactions. Compounds 2, 7, 8, and 10 displayed potential antiproliferative activity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines, while compound 1 showed weak activity against these human tumor cells.

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