Calcitonin Gene-Related Peptide Upregulates Serum Amyloid A Synthesis through Activation of Interleukin-6

Sho MATSUI; Takumi YAMANE; Kazuo KOBAYASHI-HATTORI; Yuichi OISHI

doi:10.1271/bbb.130450

Biochemistry & Molecular Biology Notes

Calcitonin Gene-Related Peptide Upregulates Serum Amyloid A Synthesis through Activation of Interleukin-6

Sho MATSUI, Takumi YAMANE, Kazuo KOBAYASHI-HATTORI, Yuichi OISHI

著者情報

キーワード: calcitonin gene-related peptide, interleukin-6, serum amyloid A, hepatocytes

ジャーナルフリー

2013 年 77 巻 10 号 p. 2151-2153

DOI https://doi.org/10.1271/bbb.130450

View "Advance Publication" version (October 7, 2013).

詳細

抄録

We found that calcitonin gene-related peptide (CGRP) enhanced the expression of levels of serum amyloid A (SAA) and interleukin-6 (IL-6) in HepG2. In addition, CGRP-induced SAA1/2 mRNA expression was blocked by an anti-IL-6 neutralizing antibody in HepG2. These results suggest that CGRP promotes SAA synthesis through activation of IL-6 in human hepatocytes.

責任著者(Corresponding author)

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