Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Food & Nutrition Science Notes
Inhibitory Effect of Methyl Methanethiosulfinate on β-Glucuronidase Activity
Yuko WATANABERyoko MUROIHaruna TSUCHIYAYasushi UDAKei HASHIMOTO
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2013 年 77 巻 11 号 p. 2325-2327

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Minced or cut-up leaves of Chinese chive (Allium tuberosum Rottler) contain thiosulfinates and their disproportionate reaction products. Among these organosulfur compounds, methyl methanethiosulfinate was found to be an uncompetitive inhibitor of β-glucuronidase. Approximately 80% of the enzyme activity was inhibited by methyl methanethiosulfinate at 50 µM, the IC50 value being comparable to 3.6 µM.
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© 2013 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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