Oral Immunization of Mice with Lily Pollen Expressing HBsAg

Hee-Sung PARK; Eun-Hye PARK; Young-Joo HEO; Yong HEO

doi:10.1271/bbb.130531

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Biochemistry & Molecular Biology Notes

Oral Immunization of Mice with Lily Pollen Expressing HBsAg

Hee-Sung PARK, Eun-Hye PARK, Young-Joo HEO, Yong HEO

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Keywords: Edible vaccine, HBsAg, lily pollen, transient expression

JOURNAL FREE ACCESS

2013 Volume 77 Issue 12 Pages 2492-2494

DOI https://doi.org/10.1271/bbb.130531

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Abstract

Lily pollen was developed to express HBsAg by Agrobacterium-mediated transformation. A double prime-boost strategy combining parenteral and oral HBsAg boosters was found to increase antibody titer levels 10-fold, as compared to a single process of priming and boosting. Lily pollen may prove a tool for oral vaccine development.

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