Maillard Reaction Inhibitors Produced by Paecilomyces sp.

Daxin LI; Kengo SHIGETOMI; Shinya MITSUHASHI; Makoto UBUKATA

doi:10.1271/bbb.130567

Organic Chemistry Note

Maillard Reaction Inhibitors Produced by Paecilomyces sp.

Daxin LI, Kengo SHIGETOMI, Shinya MITSUHASHI, Makoto UBUKATA

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Keywords: Maillard reaction inhibitor, advanced glycation end-product (AGE), Paecilomyces, (−)-mitorubrin, 4-O-demethylsilvaticol

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Supplementary material

2013 Volume 77 Issue 12 Pages 2499-2501

DOI https://doi.org/10.1271/bbb.130567

View "Advance Publication" version (December 7, 2013).

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Abstract

Maillard reaction inhibitors could be useful therapeutics for diabetes and other age-related diseases. We isolated for the first time 4-O-demethylsilvaticol (1) and (−)-mitorubrin (2) as Maillard reaction inhibitors from Paecilomyces sp. 3193B. Among the isolated inhibitors, 2 showed most potent inhibitory effect by an SDS–PAGE assay on cross-linked protein formation and by a fluorescent assay on AGE formation.

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