2013 年 77 巻 12 号 p. 2499-2501
Maillard reaction inhibitors could be useful therapeutics for diabetes and other age-related diseases. We isolated for the first time 4-O-demethylsilvaticol (1) and (−)-mitorubrin (2) as Maillard reaction inhibitors from Paecilomyces sp. 3193B. Among the isolated inhibitors, 2 showed most potent inhibitory effect by an SDS–PAGE assay on cross-linked protein formation and by a fluorescent assay on AGE formation.
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