Maillard Reaction Inhibitors Produced by Paecilomyces sp.

Daxin LI; Kengo SHIGETOMI; Shinya MITSUHASHI; Makoto UBUKATA

doi:10.1271/bbb.130567

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Maillard Reaction Inhibitors Produced by Paecilomyces sp.

Daxin LI, Kengo SHIGETOMI, Shinya MITSUHASHI, Makoto UBUKATA

著者情報

キーワード: Maillard reaction inhibitor, advanced glycation end-product (AGE), Paecilomyces, (−)-mitorubrin, 4-O-demethylsilvaticol

ジャーナルフリー早期公開
電子付録

論文ID: 130567

DOI https://doi.org/10.1271/bbb.130567

この記事には本公開記事があります。

The final version of this article is now available: Vol. 77 (2013), No. 12 pp. 2499-2501

詳細

抄録

Maillard reaction inhibitors could be useful therapeutics for diabetes and other age-related diseases. We isolated for the first time 4-O-demethylsilvaticol (1) and (−)-mitorubrin (2) as Maillard reaction inhibitors from Paecilomyces sp. 3193B. Among the isolated inhibitors, 2 showed most potent inhibitory effect by an SDS–PAGE assay on cross-linked protein formation and by a fluorescent assay on AGE formation.

責任著者(Corresponding author)

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