Lysophosphatidylcholine Potentiates BDNF-Induced TrkB Phosphorylation and Downstream Signals in Cerebellar Granule Neurons

WUHANQIMUGE; Manabu ARIOKA

doi:10.1271/bbb.130622

Biochemistry & Molecular Biology Notes

Lysophosphatidylcholine Potentiates BDNF-Induced TrkB Phosphorylation and Downstream Signals in Cerebellar Granule Neurons

WUHANQIMUGE, Manabu ARIOKA

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Keywords: Akt, brain-derived growth factor, cerebellar granule neurons, lysophosphatidylcholine, mitogen-activated protein kinase

JOURNAL FREE ACCESS

2013 Volume 77 Issue 12 Pages 2510-2513

DOI https://doi.org/10.1271/bbb.130622

View "Advance Publication" version (December 7, 2013).

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Abstract

We found that brain-derived neurotrophic factor (BDNF)-induced phosphorylation of mitogen-activated protein kinase (MAPK) and Akt in cerebellar granule neurons was specifically potentiated by LPC. LPC also augmented the BDNF-induced phosphorylation of TrkB, the receptor for BDNF. In TrkB-transfected CHO-K1 cells, LPC potentiated BDNF-induced MAPK phosphorylation. These results suggest that LPC plays a role in BDNF-TrkB signaling by regulating the activation of TrkB.

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