Absorption of Proteoglycan via Clathrin-Mediated Endocytosis in the Small Intestine of Rats

Yo TSUCHIYA; Masahiro TOMITA; Makoto TSUBOI; Tatsuji TAKAHASHI; Masato YONEZUKA; Satomi KIKUCHI; Sanae NAGASAWA; Airi KUMAZAWA; Junko KUBOTA

doi:10.1271/bbb.120773

Biochemistry & Molecular Biology Notes

Absorption of Proteoglycan via Clathrin-Mediated Endocytosis in the Small Intestine of Rats

Yo TSUCHIYA, Masahiro TOMITA, Makoto TSUBOI, Tatsuji TAKAHASHI, Masato YONEZUKA, Satomi KIKUCHI, Sanae NAGASAWA, Airi KUMAZAWA, Junko KUBOTA

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Keywords: proteoglycan, jejunum, endocytosis, clathrin

JOURNAL FREE ACCESS

2013 Volume 77 Issue 3 Pages 654-656

DOI https://doi.org/10.1271/bbb.120773

View "Advance Publication" version (March 7, 2013).

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Abstract

The mechanism underlying proteoglycan (PG) absorption in the intestine is not clear. Hence we analyzed the transport of salmon PG in the rat jejunum, ileum, and colon by the everted-sac method. The jejunum showed the largest capacity for PG transport. Jejunal transport of PG was also greater than that of chondroitin A and C. An inhibitor of clathrin-mediated endocytosis reduced jejunal PG transport. We conclude that intestinal PG transport is highest in the jejunum, and is partially dependent on clathrin-mediated endocytosis.

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