The Protective Effects of β-Cryptoxanthin on Inflammatory Bone Resorption in a Mouse Experimental Model of Periodontitis

Chiho MATSUMOTO; Noriyuki ASHIDA; Satoshi YOKOYAMA; Tsukasa TOMINARI; Michiko HIRATA; Kazunori OGAWA; Minoru SUGIURA; Masamichi YANO; Masaki INADA; Chisato MIYAURA

doi:10.1271/bbb.120791

Biochemistry & Molecular Biology Notes

The Protective Effects of β-Cryptoxanthin on Inflammatory Bone Resorption in a Mouse Experimental Model of Periodontitis

Chiho MATSUMOTO, Noriyuki ASHIDA, Satoshi YOKOYAMA, Tsukasa TOMINARI, Michiko HIRATA, Kazunori OGAWA, Minoru SUGIURA, Masamichi YANO, Masaki INADA, Chisato MIYAURA

著者情報

Chiho MATSUMOTO
Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
Noriyuki ASHIDA
Cooperative Major in Advanced Health Science, Tokyo University of Agriculture and Technology
Satoshi YOKOYAMA
Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
Cooperative Major in Advanced Health Science, Tokyo University of Agriculture and Technology
Tsukasa TOMINARI
Cooperative Major in Advanced Health Science, Tokyo University of Agriculture and Technology
Michiko HIRATA
Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
Kazunori OGAWA
National Institute of Fruit Tree Science
Minoru SUGIURA
National Institute of Fruit Tree Science
Masamichi YANO
National Institute of Fruit Tree Science
Masaki INADA
Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
Cooperative Major in Advanced Health Science, Tokyo University of Agriculture and Technology
Chisato MIYAURA
Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
Cooperative Major in Advanced Health Science, Tokyo University of Agriculture and Technology

キーワード: β-cryptoxanthin, periodontitis, osteoclast, alveolar bone

ジャーナルフリー

2013 年 77 巻 4 号 p. 860-862

DOI https://doi.org/10.1271/bbb.120791

詳細

抄録

We examined the effects of β-cryptoxanthin, a typical carotenoid, on inflammatory periodontitis. β-Cryptoxanthin suppressed lipopolysaccharide (LPS)-induced osteoclast formation in co-cultures of bone marrow cells and osteoblasts. In a mouse model of periodontitis, it suppressed bone resorption in the mandibular alveolar bone in vitro and restored alveolar bone loss induced by LPS in vivo. β-Cryptoxanthin might protect against periodontal disease.

責任著者(Corresponding author)

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