Biochemistry & Molecular Biology Notes
Versatility of Enzymes Catalyzing Late Steps in Polyene 67-121C Biosynthesis
2013 年 77 巻 4 号 p. 880-883
詳細
2013 年 77 巻 4 号 p. 880-883
Actinoplanes caeruleus produces 67-121C, a heptaene macrolide modified with a D-mannosyl-D-mycosaminyl disaccharide. Draft genome sequencing revealed genes encoding mycosaminyltransferase, mycosamine synthase, a cytochrome P450 that modifies the macrolactone core, and the extending mannosyltransferase. Only the mycosamine synthase and P450 were active in the biosynthesis of amphotericins in Streptomyces nodosus, the amphotericin producer.
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