Dietary Coenzyme Q10 Suppressed Hepatic Hydroxymethylglutaryl-CoA Reductase Activity in Laying Hens

Kazuhisa HONDA; Takaoki SANEYASU; Tohru MOTOKI; Yuriko PARK; Hiroshi KAMISOYAMA

doi:10.1271/bbb.130039

Food & Nutrition Science Notes

Dietary Coenzyme Q10 Suppressed Hepatic Hydroxymethylglutaryl-CoA Reductase Activity in Laying Hens

Kazuhisa HONDA, Takaoki SANEYASU, Tohru MOTOKI, Yuriko PARK, Hiroshi KAMISOYAMA

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Keywords: coenzyme Q10, ubiquinone, egg yolk, cholesterol

JOURNAL FREE ACCESS

2013 Volume 77 Issue 7 Pages 1572-1574

DOI https://doi.org/10.1271/bbb.130039

View "Advance Publication" version (July 7, 2013).

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Abstract

The effects of dietary coenzyme Q10 (CoQ10) on cholesterol metabolism in laying hens were investigated. Dietary CoQ10 significantly reduced egg yolk cholesterol content and suppressed hepatic hydroxymethylglutaryl-CoA reductase (HMGR) activity. It is therefore likely that CoQ10 acts as an HMGR inhibitor in the livers of laying hens, which in turn results in a reduction in egg-yolk cholesterol.

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