A Hair Growth-Promoting Effect of Chinese Black Tea Extract in Mice

I-Ching HOU; Yasuyuki OI; Hiroyuki FUJITA; Yoshihisa YANO; Harukazu FUKAMI; Masaaki YOSHIKAWA

doi:10.1271/bbb.130298

Food & Nutrition Science Communication

A Hair Growth-Promoting Effect of Chinese Black Tea Extract in Mice

I-Ching HOU, Yasuyuki OI, Hiroyuki FUJITA, Yoshihisa YANO, Harukazu FUKAMI, Masaaki YOSHIKAWA

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Keywords: hair growth, Chinese black tea extract (CBTE), estrogen receptor, C3H/He mice, capsaicin

JOURNAL FREE ACCESS

2013 Volume 77 Issue 7 Pages 1606-1607

DOI https://doi.org/10.1271/bbb.130298

View "Advance Publication" version (July 7, 2013).

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Abstract

Chinese black tea extract (CBTE) fermented with Aspergillus sp. significantly promoted hair growth after 2 weeks of topical application in shaved 6 week-old male C3H/He mice. The hair growth-promoting effect of CBTE was potentiated synergistically by capsaicin, which has no effect on hair growth by itself. CBTE displayed an affinity for estrogen receptor (ER)α, with an IC₅₀ value of 74.8 µg/mL. This effect of CBTE might be mediated by the ERs, since a similar effect induced by orally administered soy isoflavone, a mixture of ERs ligands, has been reported to be synergistically potentiated by capsaicin.

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