Role of Nuclear Localization of PSMB1 in Transcriptional Activation

Jun YAMAUCHI; Mariko SEKIGUCHI; Tomomi SHIRAI; Mami YAMADA; Yoshiko ISHIMI

doi:10.1271/bbb.130290

Biochemistry & Molecular Biology Notes

Role of Nuclear Localization of PSMB1 in Transcriptional Activation

Jun YAMAUCHI, Mariko SEKIGUCHI, Tomomi SHIRAI, Mami YAMADA, Yoshiko ISHIMI

著者情報

キーワード: retinol binding protein 4 (RBP4), proteasome subunit beta type 1 (PSMB1), insulin resistance, nuclear localization, transcription

ジャーナルフリー

2013 年 77 巻 8 号 p. 1785-1787

DOI https://doi.org/10.1271/bbb.130290

View "Advance Publication" version (August 7, 2013).

詳細

抄録

The production of retinol binding protein 4 (RBP4) is higher in adipose tissue in type 2 diabetes. We have found that proteasome subunit beta type 1 (PSMB1) is a transcriptional activator of Rbp4. In the present study, the putative tyrosine phosphorylation site in PSMB1 was mutated to phenylalanine. The mutated form of PSMB1 displayed increased nuclear translocation, resulting in activation of transcription in adipocytes.

責任著者(Corresponding author)

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