Role of Nuclear Localization of PSMB1 in Transcriptional Activation

Jun YAMAUCHI; Mariko SEKIGUCHI; Tomomi SHIRAI; Mami YAMADA; Yoshiko ISHIMI

doi:10.1271/bbb.130290

この記事には本公開記事があります。本公開記事を参照してください。
引用する場合も本公開記事を引用してください。

Role of Nuclear Localization of PSMB1 in Transcriptional Activation

Jun YAMAUCHI, Mariko SEKIGUCHI, Tomomi SHIRAI, Mami YAMADA, Yoshiko ISHIMI

著者情報

キーワード: retinol binding protein 4 (RBP4), proteasome subunit beta type 1 (PSMB1), insulin resistance, nuclear localization, transcription

ジャーナルフリー早期公開

論文ID: 130290

DOI https://doi.org/10.1271/bbb.130290

この記事には本公開記事があります。

The final version of this article is now available: Vol. 77 (2013), No. 8 pp. 1785-1787

詳細

抄録

The production of retinol binding protein 4 (RBP4) is higher in adipose tissue in type 2 diabetes. We have found that proteasome subunit beta type 1 (PSMB1) is a transcriptional activator of Rbp4. In the present study, the putative tyrosine phosphorylation site in PSMB1 was mutated to phenylalanine. The mutated form of PSMB1 displayed increased nuclear translocation, resulting in activation of transcription in adipocytes.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）