Octaphlorethol A Inhibits the CpG-Induced Inflammatory Response by Attenuating the Mitogen-Activated Protein Kinase and NF-κB Pathways

Zahid MANZOOR; Vivek Bhakta MATHEMA; Doobyeong CHAE; Hee-Kyoung KANG; Eun-Sook YOO; You-Jin JEON; Young-Sang KOH

doi:10.1271/bbb.130299

Biochemistry & Molecular Biology Notes

Octaphlorethol A Inhibits the CpG-Induced Inflammatory Response by Attenuating the Mitogen-Activated Protein Kinase and NF-κB Pathways

Zahid MANZOOR, Vivek Bhakta MATHEMA, Doobyeong CHAE, Hee-Kyoung KANG, Eun-Sook YOO, You-Jin JEON, Young-Sang KOH

著者情報

キーワード: octaphlorethol A, pro-inflammatory cytokines, mitogen-activated protein kinase, NF-κB

ジャーナルフリー

2013 年 77 巻 9 号 p. 1970-1972

DOI https://doi.org/10.1271/bbb.130299

View "Advance Publication" version (September 7, 2013).

詳細

抄録

Octaphlorethol A is a phenolic compound isolated from the marine alga Ishige foliacea. In the present study, we investigated the anti-inflammatory activity of octaphlorethol A in CpG-stimulated primary murine bone marrow-derived macrophages and dendritic cells. It exhibited anti-inflammatory activity by regulating the mitogen-activated protein kinase and NF-κB pathways.

責任著者(Corresponding author)

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