Molecular Size of Collagen Peptide Reverses the Permeability of Caco-2 Cells

Kazuo SHIMIZU; Mikako SATO; Youzuo ZHANG; Tomomi KOUGUCHI; Yoshihisa TAKAHATA; Fumiki MORIMATSU; Makoto SHIMIZU

doi:10.1271/bbb.100015

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Molecular Size of Collagen Peptide Reverses the Permeability of Caco-2 Cells

Kazuo SHIMIZU, Mikako SATO, Youzuo ZHANG, Tomomi KOUGUCHI, Yoshihisa TAKAHATA, Fumiki MORIMATSU, Makoto SHIMIZU

著者情報

キーワード: fish collagen peptide, paracellular pathway, tight junction, permeability, Caco-2 cells

ジャーナルフリー早期公開

論文ID: 100015

DOI https://doi.org/10.1271/bbb.100015

この記事には本公開記事があります。

The final version of this article is now available: Vol. 74 (2010) , No. 5 p.1123

詳細

抄録

Intestinal permeability to size-classified fish collagen peptides (FCPs) was examined using Caco-2 monolayers. Minimum-sized FCPs were most efficiently transported across the Caco-2 monolayers. Permeability depended on peptide size. It was independent of the H⁺-coupled peptide transport system but was associated with tight junction permeability, suggesting that the paracellular pathway is responsible for transepithelial transport of collagen peptides.

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