The Structural Requirements of Matriptase in Its Ectodomain Release in Polarized Epithelial Cells

Satoshi TSUZUKI; Nobuhito MURAI; Yuka MIYAKE; Kuniyo INOUYE; Tohru FUSHIKI

doi:10.1271/bbb.100074

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The Structural Requirements of Matriptase in Its Ectodomain Release in Polarized Epithelial Cells

Satoshi TSUZUKI, Nobuhito MURAI, Yuka MIYAKE, Kuniyo INOUYE, Tohru FUSHIKI

著者情報

キーワード: catalytic domain, ectodomain release, matriptase, post-translational cleavage, simple epithelial cells

ジャーナルフリー早期公開

論文ID: 100074

DOI https://doi.org/10.1271/bbb.100074

この記事には本公開記事があります。

The final version of this article is now available: Vol. 74 (2010) , No. 6 p.1295

詳細

抄録

Matriptase is a type-II transmembrane serine protease abundantly expressed in polarized epithelia. The ectodomain of matriptase is released from the cell surface. In the present study, we found that the post-translational cleavage between Gly149 and Ser150 and the existence of catalytic domain are critical for the ectodomain release of matriptase in stable transfection experiments using the polarized Madin–Darby canine kidney epithelial cell line.

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