Galangal Pungent Component, 1′-Acetoxychavicol Acetate, Activates TRPA1

Masataka NARUKAWA; Kanako KOIZUMI; Yusaku IWASAKI; Kikue KUBOTA; Tatsuo WATANABE

doi:10.1271/bbb.100133

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Galangal Pungent Component, 1′-Acetoxychavicol Acetate, Activates TRPA1

Masataka NARUKAWA, Kanako KOIZUMI, Yusaku IWASAKI, Kikue KUBOTA, Tatsuo WATANABE

著者情報

キーワード: 1′-acetoxychavicol acetate (ACA), transient receptor potential cation channel, subfamily A, member 1 (TRPA1), transient receptor potential cation channel, subfamily V, member 1 (TRPV1), intracellular Ca²⁺ concentration

ジャーナルフリー早期公開

論文ID: 100133

DOI https://doi.org/10.1271/bbb.100133

この記事には本公開記事があります。

The final version of this article is now available: Vol. 74 (2010) , No. 8 p.1694

詳細

抄録

We investigated the activation of transient receptor potential cation channel (TRP) subfamily V, member 1 (TRPV1) and TRP subfamily A, member 1 (TRPA1) by 1′-acetoxychavicol acetate (ACA), the main pungent component in galangal. ACA did not activate TRPV1-expressing human embryonic kidney (HEK) cells, but strongly activated TRPA1-expressing HEK cells. ACA was more potent than allyl isothiocyanate, the typical TRPA1 agonist.

責任著者(Corresponding author)

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