Fucoidan Isolated from Laminaria angustata var. longissima Induced Macrophage Activation

Takeshi TERUYA; Shinji TAKEDA; Yukihiro TAMAKI; Masakuni TAKO

doi:10.1271/bbb.100294

This article has now been updated. Please use the final version.

Fucoidan Isolated from Laminaria angustata var. longissima Induced Macrophage Activation

Takeshi TERUYA, Shinji TAKEDA, Yukihiro TAMAKI, Masakuni TAKO

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Keywords: Laminaria angustata var. longissima, fucoidan, macrophage activation

JOURNAL FREE ACCESS Advance online publication

Article ID: 100294

DOI https://doi.org/10.1271/bbb.100294

The final version of this article is now available: Vol. 74 (2010) , No. 9 p.1960

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Abstract

We investigated macrophage activation by fucoidan from Laminaria angustata var. longissima in a murine macrophage cell line, RAW 264.7. The ratio of the chemical composition of the fucoidan was L-fucose:D-galactose:D-glucose:D-xylose:uronic acid:sulfate = 1.00:0.54:0.08:0.08:0.64:0.87. The fucoidan induced production of nitric oxide, tumor necrosis factor-α, and interleukin-6 in RAW 264.7 cells. These results indicate that the fucoidan induced macrophage activation.

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