Fucoidan Isolated from Laminaria angustata var. longissima Induced Macrophage Activation

Takeshi TERUYA; Shinji TAKEDA; Yukihiro TAMAKI; Masakuni TAKO

doi:10.1271/bbb.100294

Biochemistry & Molecular Biology Notes

Fucoidan Isolated from Laminaria angustata var. longissima Induced Macrophage Activation

Takeshi TERUYA, Shinji TAKEDA, Yukihiro TAMAKI, Masakuni TAKO

Author information

Keywords: Laminaria angustata var. longissima, fucoidan, macrophage activation

JOURNAL FREE ACCESS

2010 Volume 74 Issue 9 Pages 1960-1962

DOI https://doi.org/10.1271/bbb.100294

View "Advance Publication" version (September 7, 2010).

Details

Abstract

We investigated macrophage activation by fucoidan from Laminaria angustata var. longissima in a murine macrophage cell line, RAW 264.7. The ratio of the chemical composition of the fucoidan was L-fucose:D-galactose:D-glucose:D-xylose:uronic acid:sulfate = 1.00:0.54:0.08:0.08:0.64:0.87. The fucoidan induced production of nitric oxide, tumor necrosis factor-α, and interleukin-6 in RAW 264.7 cells. These results indicate that the fucoidan induced macrophage activation.

Corresponding author

Register with J-STAGE for free!