Reduction of Blood Pressure by Soybean Saponins, Renin Inhibitors from Soybean, in Spontaneously Hypertensive Rats

Kazuyuki HIWATASHI; Hitoshi SHIRAKAWA; Kazuyuki HORI; Yumiko YOSHIKI; Nao SUZUKI; Mika HOKARI; Michio KOMAI; Saori TAKAHASHI

doi:10.1271/bbb.100328

This article has now been updated. Please use the final version.

Reduction of Blood Pressure by Soybean Saponins, Renin Inhibitors from Soybean, in Spontaneously Hypertensive Rats

Kazuyuki HIWATASHI, Hitoshi SHIRAKAWA, Kazuyuki HORI, Yumiko YOSHIKI, Nao SUZUKI, Mika HOKARI, Michio KOMAI, Saori TAKAHASHI

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Keywords: soyasaponin, soybean, renin inhibitor, blood pressure, spontaneously hypertensive rat

JOURNAL FREE ACCESS Advance online publication

Article ID: 100328

DOI https://doi.org/10.1271/bbb.100328

The final version of this article is now available: Vol. 74 (2010) , No. 11 p.2310

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Abstract

The effect of commercial purified soybean saponin on renin activity and blood pressure was investigated. Soybean saponin significantly inhibited human renin in vitro with IC₅₀=59.9 μg/ml. Orally administered soybean saponin at 80 mg/kg of body weight per day to spontaneously hypertensive rats for 8 weeks significantly decreased the blood pressure.

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