Reduction of Blood Pressure by Soybean Saponins, Renin Inhibitors from Soybean, in Spontaneously Hypertensive Rats

Kazuyuki HIWATASHI; Hitoshi SHIRAKAWA; Kazuyuki HORI; Yumiko YOSHIKI; Nao SUZUKI; Mika HOKARI; Michio KOMAI; Saori TAKAHASHI

doi:10.1271/bbb.100328

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Reduction of Blood Pressure by Soybean Saponins, Renin Inhibitors from Soybean, in Spontaneously Hypertensive Rats

Kazuyuki HIWATASHI, Hitoshi SHIRAKAWA, Kazuyuki HORI, Yumiko YOSHIKI, Nao SUZUKI, Mika HOKARI, Michio KOMAI, Saori TAKAHASHI

著者情報

キーワード: soyasaponin, soybean, renin inhibitor, blood pressure, spontaneously hypertensive rat

ジャーナルフリー早期公開

論文ID: 100328

DOI https://doi.org/10.1271/bbb.100328

この記事には本公開記事があります。

The final version of this article is now available: Vol. 74 (2010) , No. 11 p.2310

詳細

抄録

The effect of commercial purified soybean saponin on renin activity and blood pressure was investigated. Soybean saponin significantly inhibited human renin in vitro with IC₅₀=59.9 μg/ml. Orally administered soybean saponin at 80 mg/kg of body weight per day to spontaneously hypertensive rats for 8 weeks significantly decreased the blood pressure.

責任著者(Corresponding author)

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