Reduction of Blood Pressure by Soybean Saponins, Renin Inhibitors from Soybean, in Spontaneously Hypertensive Rats

Kazuyuki HIWATASHI; Hitoshi SHIRAKAWA; Kazuyuki HORI; Yumiko YOSHIKI; Nao SUZUKI; Mika HOKARI; Michio KOMAI; Saori TAKAHASHI

doi:10.1271/bbb.100328

Food & Nutrition Science Notes

Reduction of Blood Pressure by Soybean Saponins, Renin Inhibitors from Soybean, in Spontaneously Hypertensive Rats

Kazuyuki HIWATASHI, Hitoshi SHIRAKAWA, Kazuyuki HORI, Yumiko YOSHIKI, Nao SUZUKI, Mika HOKARI, Michio KOMAI, Saori TAKAHASHI

著者情報

キーワード: soyasaponin, soybean, renin inhibitor, blood pressure, spontaneously hypertensive rat

ジャーナルフリー

2010 年 74 巻 11 号 p. 2310-2312

DOI https://doi.org/10.1271/bbb.100328

View "Advance Publication" version (November 7, 2010).

詳細

抄録

The effect of commercial purified soybean saponin on renin activity and blood pressure was investigated. Soybean saponin significantly inhibited human renin in vitro with IC₅₀=59.9 μg/ml. Orally administered soybean saponin at 80 mg/kg of body weight per day to spontaneously hypertensive rats for 8 weeks significantly decreased the blood pressure.

責任著者(Corresponding author)

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