Antifungal Activity of Morinol B Derivatives of Tetrahydropyran Sesquilignan

Kenta MASUDA; Hisashi NISHIWAKI; Koichi AKIYAMA; Satoshi YAMAUCHI; Masafumi MARUYAMA; Takuya SUGAHARA; Taro KISHIDA

doi:10.1271/bbb.100422

This article has now been updated. Please use the final version.

Antifungal Activity of Morinol B Derivatives of Tetrahydropyran Sesquilignan

Kenta MASUDA, Hisashi NISHIWAKI, Koichi AKIYAMA, Satoshi YAMAUCHI, Masafumi MARUYAMA, Takuya SUGAHARA, Taro KISHIDA

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Keywords: morinol B, sesquilignan, antifungal activity

JOURNAL FREE ACCESS Advance online publication

Article ID: 100422

DOI https://doi.org/10.1271/bbb.100422

The final version of this article is now available: Vol. 74 (2010) , No. 10 p.2071

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Abstract

The relationship between the structure of naturally occurring (7R,7′R,8R,8′R)-morinol B and its antifungal activity was examined. 3-Demethoxy morinol B showed much higher activity than the natural compound. The activity of the 4-butoxy-3-demethoxy derivative was higher than that of 3-demethoxy morinol B.

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