Antifungal Activity of Morinol B Derivatives of Tetrahydropyran Sesquilignan

Kenta MASUDA; Hisashi NISHIWAKI; Koichi AKIYAMA; Satoshi YAMAUCHI; Masafumi MARUYAMA; Takuya SUGAHARA; Taro KISHIDA

doi:10.1271/bbb.100422

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Organic Chemistry Regular Papers

Antifungal Activity of Morinol B Derivatives of Tetrahydropyran Sesquilignan

Kenta MASUDA, Hisashi NISHIWAKI, Koichi AKIYAMA, Satoshi YAMAUCHI, Masafumi MARUYAMA, Takuya SUGAHARA, Taro KISHIDA

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Keywords: morinol B, sesquilignan, antifungal activity

JOURNAL FREE ACCESS

2010 Volume 74 Issue 10 Pages 2071-2076

DOI https://doi.org/10.1271/bbb.100422

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Abstract

The relationship between the structure of naturally occurring (7R,7′R,8R,8′R)-morinol B and its antifungal activity was examined. 3-Demethoxy morinol B showed much higher activity than the natural compound. The activity of the 4-butoxy-3-demethoxy derivative was higher than that of 3-demethoxy morinol B.

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